Mission The Institute for Cancer Research is a private non-profit institution founded by the Fondazione
Piemontese per la Ricerca sul Cancro-Onlus (FPRC) and operated by the Fondazione del
Piemonte per l'Oncologia (FPO: a joint venture between the FPRC and the Regione Piemonte). It is the seat of the Department of Oncological Sciences of the University of Torino. Its mission is to make a significant contribution to fight cancer by understanding the
basics, and by providing optimal diagnostic and therapeutic services. Both basic research and clinical research are actively performed, placing the Institute at the interface
between molecular biology and medicine. The FPRC provides enduring fund raising to complete the Institute’s buildings and to support basic research.
AIRC Special Program in Clinical Molecular Oncology
A translational research aimed at near term benefits to the patients.more
Cancer development, progression, and metastasis are highly dependent on angiogenesis. The use of antiangiogenic drugs has been proposed as a novel strategy to interfere with tumor growth, but cancer cells respond by developing strategies to escape these treatments. In particular, animal models show that antiangiogenic drugs currently used in clinical settings reduce tumor tissue oxygenation and trigger molecular events that foster cancer resistance to therapy. Here, we show that semaphorin 3A (S...
Secreted Semaphorin 3E (Sema3E) promotes cancer cell invasiveness and metastatic spreading. The pro-metastatic activity of Sema3E is due to its proteolytic fragment p61, capable of transactivating the oncogenic tyrosine kinase ErbB2 that associates with the Sema3E receptor PlexinD1 in cancer cells. Here, we show that a mutated, uncleavable variant of Sema3E (Uncl-Sema3E) binds to PlexinD1 like p61-Sema3E, but does not promote the association of PlexinD1 with ErbB2 nor activates the ensuing signa...
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Institute for Cancer Research and Treatment Strada Provinciale 142
km 3,95 10060 Candiolo,Torino-Italy
tel:
+390119933111 - fax +390119933225
Friday 18 May 2012