Cancer of Unknown Primary (CUP) identifies a heterogeneous entity characterized by the absence of an identifiable site-specific tumor of origin, early metastatic dissemination, very aggressive behavior, and undifferentiated phenotype. Representing 3-5% of all human cancers, CUPs are still an unsolved clinical problem, with elusive biology and paucity of effective therapies. Initial genomic surveys of CUPs have been presented but no actionable targets have been validated so far in the clinic. Therefore, at present, a semi-agnostic approach of systemic chemotherapy based on general histological features, rather than rational treatment tailored around hypothesis-generating molecular features, is the gold standard. Putting CUPs in the context of cancer precision medicine, as it has been done for other tumor types such as non-small cell lung cancer, remains an unmet clinical need.
Albeit rare, CUPs provide a unique model to study the common denominators of early tumor dissemination from the primary site and to illustrate the fundamental principles of the metastatization process. Accordingly, the 2017 Candiolo CUP Conference will discuss the clinical and biological complexity of CUPs. The meeting will be structured into four sessions: (1) CUPs: Drivers and Targets; (2) Cancer Stem Cells and CUPs: Understanding the Early Metastatic Phenotype; (3) CUPs: Diagnostic and Therapeutic Guidelines; (4). Cancer Precision Medicine in the Metastatic Disease

Paolo Comoglio
Candiolo Cancer Institute, Candiolo - Italy

Carla Boccaccio
Candiolo Cancer Institute, FPO-IRCCS,Cancer Stem Cell Research, Candiolo – Italy

Manel Esteller
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, - Spain

Christoph A. Klein
Experimental Medicine and Therapy Research, University of Regensburg, Regensburg - Germany

Christophe Massard
Institut Gustave Roussy, University of Paris Sud, Villejuif - France

Filippo Montemurro
Candiolo Cancer Institute, FPO-IRCCS, Investigative Clinical Oncology, Candiolo - Italy

Karin Oien
University of Glasgow, Institute of Cancer - Pathology, Glasgow – UK
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Klaus Pantel
Universitätsklinikum Hamburg-Eppendorf - Department of Tumor Biology, Hamburg - Germany

Anna Sapino
Candiolo Cancer Institute, FPO-IRCCS, Pathology Unit, Candiolo – Italy

Maurizio Scaltriti
Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program, New York - USA

Martin Sprick
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg - Germany

Livio Trusolino
Candiolo Cancer Institute, FPO-IRCCS, Translational Cancer Medicine, Candiolo - Italy



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